Comparison of drug delivery efficiency between mesh nebulizer, jet nebulizer and pMDI during noninvasive ventilation

Aerosol administration during non-invasive ventilation (NIV) is a common clinical drug administration method, but the drug administration efficiency of different drug delivery devices is different.

In a study, researchers used mesh nebulizers, jet nebulizers and pMDI, and applied different NIV masks to simulate adult lung models to explore drug administration efficiency.

Salbutamol sulfate (2.5 mg/3 ml) was nebulized in a mesh nebulizer and a jet nebulizer, and the pMDI was sprayed 4 times (108 ug/puff). The drug was eluted from the filter and analyzed by UV spectrophotometry at 276 nm.

Conclusion: In the simulated adult lung model, the use of nebulizer and mask affects the drug delivery efficiency. The drug delivery volume of the mesh nebulizer is about 7 times higher than that of the pMDI and about 2 times higher than that of the jet nebulizer.

Reference: 

AlQuaimi MM, Fink JB, Ari A. Efficiency of different aerosol devices and masks during noninvasive positive pressure ventilation in a simulated adult lung model. J Respir Med Lung Dis. 2017;2(3):1018.