A total of 70 children with wheezing pneumonia admitted to our hospital from October 2013 to December 2014 were randomly divided into an observation group (35 cases) and a control group (35 cases). The children in the control group received conventional treatment measures, while the children in the observation group received ventolin and pulmicort combined with nebulization inhalation treatment. The disappearance time of the main clinical symptoms and the occurrence of adverse reactions in the two groups were compared and observed. Results The disappearance time of the main clinical symptoms such as cough, wheezing, moist rales, and wheezing in the observation group was significantly shorter than that in the control group (P < 0.05), and the hospitalization time of the observation group was significantly shorter than that in the control group (P < 0.05). Two patients in the observation group had adverse reactions such as nausea, diarrhea, headache, and tremor, while 9 patients in the control group had adverse reactions. The incidence of adverse reactions in the observation group (5.7%) was significantly lower than that in the control group (25.7%) (P < 0.05).

1. Comparison of the disappearance time of the main clinical symptoms and hospitalization time between the two groups of patients The disappearance time of the main clinical symptoms such as cough, wheezing, moist rales and wheezing in the observation group was significantly shorter than that in the control group (P<0.05), and the hospitalization time of the observation group was significantly shorter than that in the control group (P<0.05) (see Table 1).

2. Comparison of adverse reactions between the two groups of patients Two patients in the observation group experienced adverse reactions such as nausea, diarrhea, headache and tremor, while 9 patients in the control group experienced adverse reactions. The incidence of adverse reactions in the observation group (5.7%) was significantly lower than that in the control group (25.7%) (P<0.05) (see Table 2).

  3. The results of this study showed that after the children in the observation group were treated with ventolin and Pulmicort Respules combined with nebulized inhalation on the basis of conventional comprehensive symptomatic treatment, the disappearance time of the main clinical symptoms such as cough, wheezing, moist rales, and wheezing, as well as the length of hospital stay were significantly shortened (P<0.05), and the adverse reactions such as nausea, diarrhea, headache, and tremor in the children in the observation group during treatment were reduced by 20%. This result is basically consistent with the results of Li Ru et al. [4]. It can be seen that the effect of nebulized inhalation of Pulmicort Respules combined with ventolin in children with wheezing pneumonia is good, which is beneficial to improve the clinical symptoms and signs of children.

  Pulmicort Respules is a kind of adrenocortical hormone drug, which has no halogens and has a significant inhibitory effect on respiratory tract inflammatory response. It is also beneficial to relieve respiratory hyperresponsiveness and bronchospasm symptoms [5]. The main ingredient in Pulmicort Respules is budesonide, which can strongly bind to glucocorticoid receptors. The clinical effect of subcutaneous administration is better, which is significantly higher than the treatment effect of general corticosteroid drugs. At the same time, most clinical experimental studies have shown that budesonide can effectively inhibit non-allergic inflammation and allergic inflammation induced by lymphocytes, histamine, neutrophils, mast cells, macrophages, cytokines, mediators, etc., and can also effectively improve clinical symptoms such as cough and wheezing caused by inflammatory reactions.

  The main active ingredient in ventolin is salbutamol, which is a selective β2 receptor agonist that selectively stimulates β2 receptors on bronchial smooth muscle and can also effectively dilate the bronchi [7]. The combined use of pulmicort and ventolin for aerosol inhalation can effectively increase the drug concentration in the patient's body, promote the regeneration of airway epithelial cells, repair the damaged airway as soon as possible, better improve the clinical symptoms of children, and minimize the pain and discomfort of children. Moreover, during the entire medication process, it will not cause adverse effects on the patient's physiological functions, and the treatment safety is relatively high. In summary, the clinical effect of Ventolin and Pulmicort Respules combined with nebulized inhalation in the treatment of children with wheezing pneumonia is good, which can effectively improve the clinical symptoms of children and help them to be discharged from the hospital as soon as possible, and the children have relatively few adverse reactions. It is a safe and effective treatment plan with high value for clinical promotion and reference.

Reference:

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[3] Gu Jiachang. Observation on the efficacy of nebulization inhalation of Pulmicort Respules combined with Ventolin in the treatment of asthmatic pneumonia in children [J]. Medical Review, 2013, 19(19): 3624-3625.

[4] Li Ru. Observation on the efficacy of triple nebulization inhalation of Pulmicort Respules, Atrovent and Ventolin in the treatment of acute exacerbation of severe asthma in adults [J]. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(3): 291-294.

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